11 articles - From Friday Dec 09 2022 to Friday Dec 16 2022
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Rheumatology (Oxford) |
RCT, clinical trials, retrospective studies, etc…
| Arthritis Care Res (Hoboken) |
Changes and associations between gait biomechanics and knee inflammation after aspiration and corticosteroid injection for knee osteoarthritis. In patients with knee OA and synovitis, reduced inflammation and pain after aspiration and corticosteroid injection is associated with changes in knee gait biomechanics and strength. |
Sleep disturbance improves with SARS-COV2 vaccinations in patients with Chronic Inflammatory Disease. Sleep disturbance decreased in a significant and meaningful way in patients with CID upon vaccination. In patients with higher baseline anxiety, social participation increased and anxiety, fatigue, and sleep disturbance decreased. Overall, results suggest that SARS-CoV-2 vaccines may improve mental health and wellbeing, particularly among those with greater anxiety. |
| Arthritis Res Ther |
Novel alendronate-CGS21680 conjugate reduces bone resorption and induces new bone formation in post-menopausal osteoporosis and inflammatory osteolysis mouse models. Histological analysis showed that MRS7216 treatment significantly reduced osteoclast number and increased osteoblast number in murine models. Interestingly, cultured human osteoclast differentiation was inhibited, and osteoblast differentiation was stimulated by the compound indicating that MRS7216 conjugates represent a novel therapeutic approach to treat osteoporosis and osteolysis. |
| Arthritis Rheumatol |
Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ NR4A1, NR4A2, and NR4A3 are important regulators of immunosuppressive and fibrosis-associated pathways in SSc cDCs. Thus, the NR4A family represents novel potential targets to restore cDC homeostasis in SSc. |
| Rheumatology (Oxford) |
A novel estrogen receptor 1-sphingomyelin phosphodiesterase acid like 3B pathway mediates rituximab response in myositis patients. In addition to B cell depletion, rituximab may be beneficial in myositis due to increased ESR1 signalling mediated by rituximab binding to SMPDL3B on skeletal muscle cells. |
Infantile Takayasu: clinical features and long-term outcome. This study presents the largest series of infantile TA. Compared with other reported series on older children, infants with TA have more severe disease and were more likely to receive biologic agents, develop complications, and require invasive interventions. |
Non-Inflammatory Pain in Inflammatory Arthritis. Lastly, we reviewed potential pathogenic mechanisms which included inflammatory cytokines sensitizing nociceptive neurones, temporal summation, also known as windup, from chronic pain and impaired coping from poor quality sleep and mental well-being. Deciphering the exact mechanisms may lead to treatment strategies that prevent development of secondary fibromyalgia and will address a common factor associated with difficult to treat RA. |
Systemic lupus erythematosus incidence and prevalence in a large population-based study in northeastern Italy. Over the last decade, SLE prevalence has increased, while incidence has stably declined. In view of the introduction of new high-cost drugs, a clear definition of the epidemiology of SLE is crucial for al healthcare stakeholders. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Care Res (Hoboken) |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Rheumatology (Oxford) |
Letters to the editors and authors’ replies